RECENT POSTS

ALS, a cellular whodunit on motor neuron degeneration

07/07/2020
ALS


Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP-43-related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS)

06/07/2020
ALS


A placebo-controlled trial to investigate the safety and efficacy of Penicillin G/Hydrocortisone in patients with ALS (PHALS trial)

06/07/2020
ALS


Exciting Complexity: The Role of Motor Circuit Elements in ALS Pathophysiology

06/07/2020
ALS


Dysregulation of steroid hormone receptors in motor neurons and glia associates with disease progression in ALS mice

05/07/2020
ALS


Quantitative patterns of motor cortex proteinopathy across ALS genotypes

03/07/2020
ALS


MCR-ALS analysis of (1)H NMR spectra by segments to study the zebrafish exposure to acrylamide

03/07/2020
ALS


Correction to: Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD

02/07/2020
ALS


Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients

01/07/2020
ALS


Mutations in the SIGMAR1 gene cause a distal hereditary motor neuropathy phenotype mimicking ALS: Report of two novel variants

30/06/2020
ALS


Resistance to acetolactate synthase inhibitors is due to a W 574 to L amino acid substitution in the ALS gene of redroot pigweed and tall waterhemp

30/06/2020
ALS


Measuring quality of life in ALS/MND: validation of the WHOQOL-BREF

29/06/2020
ALS


Absence of subcerebral projection neurons is beneficial in a mouse model of ALS

26/06/2020
ALS


Revisiting the complex architecture of ALS in Turkey: Expanding genotypes, shared phenotypes, molecular networks, and a public variant database

25/06/2020
ALS


Needling the future in ALS

20/06/2020
ALS


Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS

20/06/2020
ALS


Spreading in ALS: The relative impact of upper and lower motor neuron involvement

19/06/2020
ALS


Levels of clusterin, CD5L, ficolin-3, and gelsolin in ALS patients and controls

19/06/2020
ALS


Lemon Balm Extract ALS-L1023 Regulates Obesity and Improves Insulin Sensitivity via Activation of Hepatic PPARα in High-Fat Diet-Fed Obese C57BL/6J Mice

18/06/2020
ALS


The conserved multi-functional nuclear protein dss-1/Sem1 is required for C9orf72-associated ALS/FTD dipeptide toxicity

18/06/2020
ALS


Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls

11/06/2020
ALS


Improved ALS clinical trials through frequent at-home self-assessment: a proof of concept study

09/06/2020
ALS


Cell-Clearing Systems Bridging Repeat Expansion Proteotoxicity and Neuromuscular Junction Alterations in ALS and SBMA

09/06/2020
ALS


Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD

09/06/2020
ALS


ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function

09/06/2020
ALS


The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS

08/06/2020
ALS


Abnormal Serum Iron-Status Indicator Changes in Amyotrophic Lateral Sclerosis (ALS) Patients: A Meta-Analysis

08/06/2020
ALS


Disease propagation in amyotrophic lateral sclerosis (ALS): an interplay between genetics and environment

08/06/2020
ALS


Malnutrition at diagnosis in amyotrophic lateral sclerosis (als) and its influence on survival: Using glim criteria

08/06/2020
ALS


5-HT2A/B receptor expression in the phrenic motor nucleus in a rat model of ALS (SOD1(G93A))

08/06/2020
ALS


In vivo histopathological staging in C9orf72-associated ALS: A tract of interest DTI study

08/06/2020
ALS


Intralingual administration of AAVrh10-miRSOD1 improves respiratory but not swallowing function in a SOD1 mouse model of ALS

05/06/2020
ALS


Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS

05/06/2020
ALS


Common mutations of interest for the diagnosis of amyotrophic lateral sclerosis: how common are common mutations in ALS genes?

05/06/2020
ALS


Blowing Hot and Cold in ALS: The Duality of TBK1

05/06/2020
ALS


From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline

03/06/2020
ALS


Tau deposition in the spinal cord is not specific for CTE-ALS

03/06/2020
ALS


Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS

03/06/2020
ALS


Correction: Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model

02/06/2020
ALS


FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention

01/06/2020
ALS


CRISPR/Cas9-Mediated Gene Correction to Understand ALS

31/05/2020
ALS


Tailored treatment for ALS poised to move ahead

29/05/2020
ALS


Differences between South African and Portuguese ALS cohorts from an environmental perspective

28/05/2020
ALS


Regulation of ALS-Associated SOD1 Mutant SUMOylation and Aggregation by SENP and PIAS Family Proteins

28/05/2020
ALS


Detection of melamine and sucrose as adulterants in milk powder using near-infrared spectroscopy with DD-SIMCA as one-class classifier and MCR-ALS as a means to provide pure profiles of milk and of both adulterants with forensic evidence: A short communic

28/05/2020
ALS


Detection of melamine and sucrose as adulterants in milk powder using near-infrared spectroscopy with DD-SIMCA as one-class classifier and MCR-ALS as a means to provide pure profiles of milk and of both adulterants with forensic evidence: A short communic

28/05/2020
ALS


Detection of melamine and sucrose as adulterants in milk powder using near-infrared spectroscopy with DD-SIMCA as one-class classifier and MCR-ALS as a means to provide pure profiles of milk and of both adulterants with forensic evidence: A short communic

27/05/2020
ALS


Detection of melamine and sucrose as adulterants in milk powder using near-infrared spectroscopy with DD-SIMCA as one-class classifier and MCR-ALS as a means to provide pure profiles of milk and of both adulterants with forensic evidence: A short communic

27/05/2020
ALS


ASC-Exosomes Ameliorate the Disease Progression in SOD1(G93A) Murine Model Underlining Their Potential Therapeutic Use in Human ALS

27/05/2020
ALS


The Role of the Microbiota-Gut-Brain Axis and Antibiotics in ALS and Neurodegenerative Diseases

27/05/2020
ALS


Detection of melamine and sucrose as adulterants in milk powder using near-infrared spectroscopy with DD-SIMCA as one-class classifier and MCR-ALS as a means to provide pure profiles of milk and of both adulterants with forensic evidence: A short communic

27/05/2020
ALS


Mitigation of ALS pathology by neuron-specific inhibition of nuclear factor kappa B signaling

27/05/2020
ALS


Author Correction: De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies

27/05/2020
ALS


Mechanisms Regulating the UPS-ALS Crosstalk: The Role of Proteaphagy

23/05/2020
ALS


Auditory Electrooculogram-based Communication System for ALS Patients in Transition from Locked-in to Complete Locked-in State

22/05/2020
ALS


Advance care planning and mental capacity in ALS: a current challenge for an unsolved matter

21/05/2020
ALS


Neuroprotective Fragment C of Tetanus Toxin Modulates IL-6 in an ALS Mouse Model

20/05/2020
ALS


Optimizing Telemedicine to Facilitate ALS Clinical Trials

17/05/2020
ALS


Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS

15/05/2020
ALS


Frameshift peptides alter the properties of truncated FUS proteins in ALS-FUS

14/05/2020
ALS


Diagnostic delay among ALS patients: Egyptian study

14/05/2020
ALS


Understanding the needs of people with ALS: a national survey of patients and caregivers

14/05/2020
ALS


Burden of Rare Variants in ALS and Axonal Hereditary Neuropathy Genes Influence Survival in ALS: Insights from a Next Generation Sequencing Study of an Italian ALS Cohort

14/05/2020
ALS


Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V

14/05/2020
ALS


A proposal for new diagnostic criteria for ALS

12/05/2020
ALS


Photostability study of multicomponent drug formulations via MCR-ALS: The case of the hydrochlorothiazide-amiloride mixture

12/05/2020
ALS


Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS

09/05/2020
ALS


Oligogenicity, C9orf72 expansion, and variant severity in ALS

09/05/2020
ALS


How I managed to stop the progression of ALS

09/05/2020
ALS


Transmission of ALS pathogenesis by the cerebrospinal fluid

08/05/2020
ALS


ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs

08/05/2020
ALS


Studying ALS: Current Approaches, Effect on Potential Treatment Strategy

08/05/2020
ALS


Presynaptic Homeostasis Opposes Disease Progression in Mouse Models of ALS-Like Degeneration: Evidence for Homeostatic Neuroprotection

08/05/2020
ALS


Functional characterization of a FUS mutant zebrafish line as a novel genetic model for ALS

08/05/2020
ALS


Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation

07/05/2020
ALS


Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo

07/05/2020
ALS


Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1(G93A) Mice Predates Disease Onset and Is A Promising Therapeutic Target

06/05/2020
ALS


Does the presenting phenotype predict survival in ALS-FTD?

05/05/2020
ALS


REM sleep physiology and selective neuronal vulnerability in amyotrophic lateral sclerosis

05/05/2020
ALS


In vivo stress granule misprocessing evidenced in a FUS knock-in ALS mouse model

03/05/2020
ALS


CCR2 is localized in microglia and neurons, as well as infiltrating monocytes, in the lumbar spinal cord of ALS mice

01/05/2020
ALS


Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis

01/05/2020
ALS


Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment

30/04/2020
ALS


Application of the area correlation constraint in the MCR-ALS quantitative analysis of complex mixture samples

29/04/2020
ALS


Cytoplasmic localization of amyotrophic lateral sclerosis (ALS)-related TDP-43 proteins modulates stress-granule formation

29/04/2020
ALS


Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment

29/04/2020
ALS


Preparation and characterization of metformin hydrochloride controlled-release tablet using fatty acid coated granules

28/04/2020
ALS


Parkinsonism in C9orf72 expansion without co-existing Lewy body pathology; a case report and review of the literature

28/04/2020
ALS


A comparative study of South African and Portuguese amyotrophic lateral sclerosis cohorts

28/04/2020
ALS


CAG repeats ≥ 34 in Ataxin-1 gene are associated with amyotrophic lateral sclerosis in a Brazilian cohort

28/04/2020
ALS