Blowing Hot and Cold in ALS: The Duality of TBK1

ALS
05/06/2020

Mayl K and Sreedharan J. Neuron 2020.

ABSTRACT

Mutations in TANK-binding kinase 1 (TBK1) are linked to ALS-FTD. In this issue of Neuron, Gerbino et al. (2020) show how missense mutations in the kinase domain of TBK1 differentially affect disease onset and progression in an ALS mouse model.