Cao H, et al. J Biomed Mater Res A 2020.
Chemical groups of microenvironment play an important role in the adhesion, proliferation, and apoptosis of tumor cells. The different chemical groups (-CH3 , -OH, -COOH) were grafted on the surfaces with the same density by Self-Assembly Monolayer (SAM) technique to introduce the influence of different microenvironments of the human bladder cancer (5637) cells. The results indicated that the 5637 cells on -COOH surface exhibited the lowest proliferation rate and the highest apoptosis rate on the first and fifth day because of negative charge and polarity of the -COOH group, which might help optimize biomedicine materials and find new methods to treat bladder cancer. This article is protected by copyright. All rights reserved.