Harnessing Natural Killer Cell Function for Genitourinary Cancers

Bladder Cancer

Urol Clin North Am. 2020 Nov;47(4):433-442. doi: 10.1016/j.ucl.2020.07.002. Epub 2020 Sep 2.


Natural killer (NK) cells are potently cytolytic innate lymphocytes involved in the immune surveillance of tumors and virally infected cells. Although much progress has been made in manipulating the ability of T cells to recognize and eliminate tumors, a comprehensive understanding of NK-cell infiltration into solid tumors, and their amenability to immunomodulation, remains incomplete. This article discusses recent studies showing that urologic tumors are infiltrated by NK cells and that these

NK cells are often dysfunctional, but that strategies interfering with inhibitory axes have significant potential to alleviate this dysfunction.