Docking analysis of importin-11 homology model with the phyto compounds towards colorectal cancer treatment

Colorectal Cancer

Selvaraj J, et al. Bioinformation 2020.


Colorectal cancer (CRC) is the most familiar malignancy worldwide. Hence, searching for novel therapeutic options is of highest priority. Therefore, it is of interest to design inhibitors to the protein target importin-11, which transports β-catenin linked to colon cancer cells. However, the structure of importin-11 is not known. Hence, we use a homology model of importin-11 to dock potential interactions with five phyto compounds using molecular interaction features for further consideration.