Carriage of Colibactin-producing Bacteria and Colorectal Cancer Risk

Colorectal Cancer

Dubinsky V, et al. Trends Microbiol 2020.


Colibactin is a genotoxic molecule, produced primarily by Escherichia coli. Colibactin causes DNA damage that may lead to colorectal cancer. Here we review recent advances in the study of colibactin and propose a focus on patients with inflammatory bowel diseases (IBD) who have higher levels of colibactin-producing bacteria in their intestines.