The Hippo Show Must Go On: YAP Activation as a Therapeutic Strategy in Colorectal Cancer

Cell Stem Cell. 2020 Oct 1;27(4):501-502. doi: 10.1016/j.stem.2020.09.007.

ABSTRACT

The role of Hippo pathway in colorectal cancer (CRC) initiation and progression has been controversial. In this issue of Cell Stem Cell, Cheung et al. (2020) shed new light on a distinct function of the transcriptional co-activator YAP as a tumor suppressor and Wnt pathway inhibitor in CRC.