Cell Stem Cell. 2020 Oct 1;27(4):501-502. doi: 10.1016/j.stem.2020.09.007.
The role of Hippo pathway in colorectal cancer (CRC) initiation and progression has been controversial. In this issue of Cell Stem Cell, Cheung et al. (2020) shed new light on a distinct function of the transcriptional co-activator YAP as a tumor suppressor and Wnt pathway inhibitor in CRC.