Novel Immunotherapeutic Approaches in Head and Neck Cancer

Head and Neck Cancer
14/07/2020

Heft Neal ME, et al. J Cancer Metastasis Treat 2019.

ABSTRACT

Unresectable recurrent or metastatic head and neck cancer is an incurable disease with survival of approximately 12 months. Head and neck tumors exhibit numerous derangements in the tumor microenvironment that aid in immune evasion and may serve as targets for future therapies. Pembrolizumab is now approved as a first line therapy. Despite the promise of currently approved immunotherapies there continues to be low response rates and additional strategies are needed. Here, alterations in the


immune microenvironment and current therapeutic strategies are reviewed with a focus on novel immunologic approaches.