JRSM Open. 2020 Jul 8;11(7):2054270420921066. doi: 10.1177/2054270420921066. eCollection 2020 Jul.
Head and neck carcinoma of unknown primary accounts for approximately 1-5% of all head and neck cancers and presents a genuine diagnostic and therapeutic dilemma. Despite advanced investigations, the primary tumour location remains unknown in up to 40% of these cases. Transoral robotic surgery presents a viable diagnostic and therapeutic option in these patients. This surgical innovation alongside advances in the understanding of head and neck cancer biology means that a multidisciplinary
approach in the management of these complex patients is of utmost importance to ensure optimal therapeutic outcomes.