Yu G and Hu J. Postgrad Med 2020.
Introduction: The treatment for locally advanced squamous non-small cell lung cancer is still challenging. Drug-eluting beads bronchial arterial chemoembolization (DEB-BACE) is a novel drug delivery and embolization system for lung cancer that has the potential to improve outcomes and reduce the incidence of adverse events (AEs). It is very rare to administer DEB-BACE as neoadjuvant therapy for lung cancer and achieve pathological complete response (pCR). Body: A 69-year-old male was hospitalized because of cough and hemoptysis caused by locally advanced squamous non-small cell lung cancer. According to his choice, he received DEB-BACE treatment without obvious AEs. After the DEB-BACE treatment, the pulmonary lesion was controlled and lobectomy was performed. Postoperative pathology showed pCR. The patient has recovered well. Conclusion: This was the first case of DEB-BACE as a neoadjuvant therapy and achieved pCR for lung cancer. DEB-BACE might be a new neoadjuvant therapy option for locally advanced non-small cell lung cancer, especially for squamous cell cancer.