Cai H, et al. Int J Cancer 2020.
Red meat or saturated fatty acid (SFA) intake has been reported to increase lung cancer (LC) risk in several western countries. However, in Asia, studies on the relationship of meat and SFA intake with LC incidence are still relatively insufficient, and their conclusions are inconsistent. We investigated the association of meat and SFA intake with LC incidence in a population-based prospective cohort study in Japan. Cox regression was used to estimate the hazard ratio (HR) and 95% confidence
interval (CI) for LC risk according to meat intake and SFA intake. A total of 73,187 participants (32,934 men and 40,253 women) aged 45-74 years participated in this study. During the follow-up period of 1,151,839 person-years (median, 16.0 year) from 1995 to 2013 for cohort I and from 1998 to 2013 for cohort II, 1,315 (901 men and 414 women) newly diagnosed cases of LC were identified. In men, we found an adverse association between total red meat intake (HR and 95% CI, 1.25 [1.02-1.53]; P-trend =0.008) and LC risk. Additionally, borderline statistically significant elevated risks of LC were seen with high intake of unprocessed red meat and processed red meat. However, no positive association between total red meat intake and LC risk was observed in women. By contrast, poultry and fish intake were not associated with LC risk in either men or women. We concluded that a high total intake of total red meat was associated with moderately elevated LC risk in men. This article is protected by copyright. All rights reserved.