Radioactive Gold Nanoparticle in Two Forms ((_79^198)Au GNPs and 99mTc-GNPs) for Lung Cancer Antiproliferative Induction and Intralesional Imaging: A Proof of Concept

Lung Cancer
30/05/2020

Xu H, et al. Anticancer Agents Med Chem 2020.

ABSTRACT

BACKGROUND: Lung cancer is among the most common cancers worldwide, responsible for 13% of all new cancer cases. Also, is the leading cause of cancer death among both men and women. In this scenario, an effective and efficient treatment is required.

OBJECTIVE: Production of two gold nanoparticles: 198Au and 99mTc-Au. The first one has been directed produced from irradiation of the 197Au in order to produce a beta-emitter gold nanoparticle for cancer therapy. The second one, has been directed produced from the radiolabeling of gold nanoparticles with technetium 99 metastable in order to produce imaging nanoagent.

METHODS: The 198Au Nanoparticles were produced by irradiation and identified by hyper-purity germanium (HPGe). Then were evaluated in vitro in order to confirm the behavior on cell proliferation of lung cancer cell line, by the MTT methodology using A549 cells. The 99mTc-Au nanoparticles were produced by direct-radiolabeling with 99mTc and evaluated in vivo as intralesional nanoagent.

RESULTS: The results showed that in both cases, all the nanoparticles have performed their duties with excellence. The 198Au nanoparticles were capable to kill lung cancer cells, while and 99mTc-Au was capable to image the tumor after intralesional injection. Also, 99mTc-Au nanoparticles were useful for biodistribution assay imaging, showing the main organs responsible for the nanoparticle uptake in healthy animals.

CONCLUSION: The both gold nanoparticles showed to be a highly efficient nanoagent for both: therapy and diagnosing of lung cancer.