Lung cancer and intraocular metastasis in gestation: Clinical experiences of a rare case

Lung Cancer

Thorac Cancer. 2020 Jul 21. doi: 10.1111/1759-7714.13572. Online ahead of print.


Lung cancer in pregnancy combined with intraocular metastasis rarely occurs and has a poor prognosis. Here, we report an extremely rare case of a 31-year-old non-smoking pregnant female who was diagnosed with lung adenocarcinoma with multiple metastasis including choroidal metastasis. Whole exon sequencing was performed but no appropriate therapeutic target was identified. The patient received standard pemetrexed plus carboplatin for first-line treatment after delivery. Ophthalmic treatment

including transpupillary thermotherapy and intravitreal ranibizumab injections were administered and the patient responded very well to treatment. Her visual acuity was restored, indicating systemic therapy combined with ophthalmic treatment was an appropriate choice of therapy. KEY POINTS: SIGNIFICANT FINDINGS OF THE STUDY: The case reported here of a pregnant female diagnosed with lung cancer with choroidal metastasis highlights the aggressive characteristics of the disease. WHAT THIS STUDY ADDS: Systemic therapy in combination with ocular therapy is an appropriate choice of treatment.