Application of Organoids in Lung Cancer Precision Medicine

Lung Cancer

Zhongguo Fei Ai Za Zhi. 2020 Jul 20;23(7):615-620. doi: 10.3779/j.issn.1009-3419.2020.101.20.


Precision medicine is an approach to rational treatment selection in the overall management of lung cancer nowadays. The introduction of the patient-derived organoid (PDO) model has established the "black-box" decision-making system from the perspective of in-vitro functional models. This may assist as a complement to the treatment selection strategy based on gene-drug correlation. Further validation must be done in multi-dimensional characteristics recapitulation of the primary tumor in

organoids and in large-scale randomized controlled clinical trials. This article will give an introduction to the organoid model and review the application scenarios of organoids in the context of the precise treatment of existing lung cancer.