Utility of immune checkpoint inhibitors in non-small-cell lung cancer patients with poor performance status

Lung Cancer

Cancer Sci. 2020 Jul 29. doi: 10.1111/cas.14590. Online ahead of print.


Most clinical trials of non-small-cell lung cancer (NSCLC) exclude patients with poor Eastern Cooperative Oncology Group performance status (PS). Thus, the efficacy of immune checkpoint inhibitors (ICIs) in patients with poor PS remains unclear. Herein, we used data from a retrospective cohort to assess the potential clinical benefits of ICIs in NSCLC patients with poor PS. Data from NSCLC patients who received ICI monotherapy at nine institutions between December 2015 and May 2018 were

retrospectively analyzed. After excluding 4 patients who lacked PS data, a total of 527 ICI-treated patients, including 79 patients with PS 2 or higher, were used for our analyses. The progression-free survival (PFS) and overall survival (OS) of patients with PS 2 or higher were significantly shorter compared with those of PS 0-1 patients median PFS, 4.1 vs. 2.0 months; p < 0.001 and median OS, 17.4 vs. 4.0 months; p < 0.001). Among NSCLC patients with PD-L1 expression ≥ 50% who were treated with pembrolizumab as first-line therapy, the median PFS times of patients with PS 2 and 0-1 were 7.3 and 8.1 months, respectively. There was no significant difference in PFS between patients with PS 2 and 0-1 (p = 0.321). Although poor PS was significantly associated with worse outcomes in NSCLC patients treated with ICIs, administration of pembrolizumab as a first-line treatment in NSCLC patients expressing high levels of PD-L1 may provide a clinical benefit, even in patients with PS 2.