Comprehensive analysis of the mechanism and treatment significance of Mucins in lung cancer

Lung Cancer
18/08/2020

J Exp Clin Cancer Res. 2020 Aug 17;39(1):162. doi: 10.1186/s13046-020-01662-3.

ABSTRACT

Aberrant expression of mucin proteins has played a complex and essential role in cancer development and metastasis. Members of the mucin family have been intimately implicated in lung cancer progression, metastasis, survival and chemo-resistance. During the progression of lung cancer, mucin proteins have involved all of the procession of lung cancer, which is interacted with many receptor tyrosine kinases signal pathways and mediated cell signals for tumor cell growth and survival. Mucins thus


have been considerable as the indicator of negative prognosis and desirable therapeutic targets of lung cancers. In this review, we comprehensively analyzed the role of each member of the mucin family in lung cancer by combining open-accessed database analysis and assembling cutting-edge information about these molecules.