Lung cancer and diabetes: a role for Advanced Glycation End-products ?

Lung Cancer

Eur J Clin Invest. 2020 Aug 27:e13389. doi: 10.1111/eci.13389. Online ahead of print.


We were interested by the article from Yi et al on the association between diabetes and lung cancer (1). Although the relation was significant only for women, the studies included in the meta-analysis were heterogenous and significance were obtained in some subgroups, like overweighted subjects. The authors hypothesized that hyperinsulinemia and chronic inflammation, as observed in obesity, may play a role in the development of lung cancers in persons with diabetes, but they also mentioned

hyperglycaemia as a mechanism.