The prognostic role of age in primary cutaneous B-cell lymphoma: a proposal derived from a population-based registry

Lymphoma
09/05/2020

Jia X, et al. Aging Clin Exp Res 2020.

ABSTRACT

PURPOSE: A few prognostic predicting systems existed for primary cutaneous B-cell lymphoma (PCBCL). However, none of them took age into consideration. We sought to declare the prognostic role of age in PCBCL.

MATERIALS AND METHODS: A total of 4859 patients were identified in the surveillance, epidemiology and end results data, spanning 1975-2016. The association between age and survival was determined using unadjusted and adjusted proportional hazard analysis.

RESULTS: There was a uni-modal distribution of age, with most in the seventh decade (22%), followed by the sixth and eighth decades (19%). As a continuous variable, age was demonstrated to have an adverse effect on overall survival (OS, HR, 1.077, 95% CI 1.073-1.082, p = 0.000) and cancer-specific survival (CSS, HR, 1.099, 95% CI 1.092-1.106, p = 0.000) after adjusted proportional hazard analysis. Patients aged ≤ 60 years had significantly higher survival rates than those aged > 60 (5-year OS was 93% vs 64%, 10-year OS was 90% vs 45%, p = 0.000; 5-year CSS was 98% vs 80%, 10-year CSS 96% was 62%, p = 0.000). Similar survival trends were also observed in different sub-group analyses, including disease with different stages (p = 0.000), different histology subgroups (p = 0.000), and different sites (p = 0.000).

CONCLUSION: Age has an important effect on overall survival and cancer-specific survival. The addition of age to the primary site, histology, and stage improves predicting long-term outcomes in cutaneous B-cell lymphoma.