Lymphomatous Adult T-cell Leukemia/Lymphoma with Anaplastic Morphology in a Country non-Endemic for HTLV: A Mimicker of Anaplastic Large Cell Lymphoma


Li CH, et al. Histopathology 2020.


Adult T-cell leukemia/lymphoma (ATLL) is a peripheral (mature) T-cell lymphoma (PTCL) caused by human T-cell leukaemia virus type 1 (HTLV-I). HTLV-I is prevalent in Japan, the Caribbean, Romania, and certain regions of Africa and Latin America. Taiwan is a country non-endemic for HTLV-I infection, with a low seroprevalence rate at 0.058-1.72%. ATLL shows diverse clinical manifestations and histology with several clinical variants including acute, lymphomatous, chronic, and smoldering.