Diagnosis of Intracranial Primary Central Nervous System Lymphoma Based on Magnetic Resonance Imaging


Chen L, et al. Neurosci Lett 2020 - Review.


OBJECTIVE: To analyse the traditional MRI signs, diffusion weighted imaging (DWI), perfusion weighted imaging (PWI), and hydrogen proton magnetic resonance spectroscopy (1H-MRS) of intracranial primary central nervous system lymphoma in immunocompetent people. To explore its diagnostic value.

METHODS: The paper retrospectively analysed the MRI signs of 12 patients with primary central nervous system lymphoma confirmed by surgery and pathology.

RESULTS: Twelve patients were all B-cell lymphoma. A total of 13 nodules were detected, 11 were single and 1 was multiple. Lesions T1WI showed low or equal signal shadows, T2WI showed equal, slightly higher, high signal shadows, DWI showed high and low signal shadows; the boundaries of the lesions were clearer, and mild to moderate enema was visible around them; most of the lesions showed obvious uniform enhancement and "gap" Signs "and" spike signs "; 1H-MRS showed a moderate decrease in N-acetyl aspartate (NAA) peak, an increase in choline (Cho) peak, and a slight decrease in creatine (Cr) peak, which can be seen Huge lipid peak. Perfusion-weighted imaging suggested that the lesions were hypoperfusion nodules.

CONCLUSION: The combined application of traditional magnetic resonance imaging, diffusion weighted imaging, perfusion weighted imaging, and 1H-MRS can improve the diagnosis rate of primary central nervous system lymphoma.