Anaplastic Lymphoma Kinase (ALK) Inhibitor in Treatment of Inflammatory Myofibroblastic Tumor of the Tongue in Infancy


J Pediatr Hematol Oncol. 2020 Aug 4. doi: 10.1097/MPH.0000000000001907. Online ahead of print.


Inflammatory myofibroblastic tumors (IMTs) are rare in neonates. IMTs of the tongue are also very rare in infancy, with only 1 case reported in this age group. The mainstay of therapy has traditionally been surgery, which can be devastating to surrounding structures and negatively impact prognosis. Approximately 50% of IMTs harbor a translocation involving the anaplastic lymphoma kinase gene. We describe a case of IMT of the tongue in a neonate treated with debulking and an anaplastic lymphoma

kinase inhibitor. The patient achieved complete response and remains disease-free 1.5 year following completion of therapy.