Concurrent Subcutaneous Panniculitis-like T-Cell Lymphoma and B-Cell Acute Lymphoblastic Leukemia in 2 Pediatric Patients


J Pediatr Hematol Oncol. 2020 Aug 26. doi: 10.1097/MPH.0000000000001921. Online ahead of print.


Subcutaneous panniculitis-like T-cell lymphoma is a cutaneous lymphoma characterized by CD8 T-cell infiltrate in the subcutis that is rare in children. Acute lymphoblastic lymphoma is the most common pediatric malignancy and often presents with fevers and pancytopenia. Herein, we report 2 pediatric patients presenting with subcutaneous panniculitis-like T-cell lymphoma and B-cell acute lymphoblastic lymphoma, distinct hematologic malignancies arising from different lymphoid lineages, with no

identifiable germline cancer predisposition.