Targeting the DNA damage response for patients with lymphoma: Preclinical and clinical evidences

Lymphoma
07/09/2020

Cancer Treat Rev. 2020 Aug 19;90:102090. doi: 10.1016/j.ctrv.2020.102090. Online ahead of print.

ABSTRACT

The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be exploited therapeutically. Specifically, we will focus on CHK1, WEE1, ATR, DNA-PK and PARP inhibitors, for


which preclinical data as single agents or in combination has been accumulating, fostering their clinical development. The few available clinical data on these inhibitors will also be discussed.