Ocul Oncol Pathol. 2020 Oct;6(5):318-322. doi: 10.1159/000508890. Epub 2020 Sep 7.
A 69-year-old female presented with right vitreous cells and cystoid macular oedema (CMO). One year previously, she had received two cycles of attenuated methotrexate-based chemotherapy for primary central nervous system (CNS) lymphoma, abandoned due to toxicity. There was no past ocular history of note aside from mild cataract. Due to her history of previous CNS lymphoma, we suspected vitreoretinal lymphoma (VRL), but the presence of the CMO made this unlikely. She underwent a diagnostic
vitrectomy. Histology and immunohistochemistry showed the presence of a high-grade B-cell VRL.