Immunohistochemistry Analysis of Itch and Pain Mediators in Nonmelanoma Skin Cancer

Skin Cancer

Fowler E, et al. J Eur Acad Dermatol Venereol 2020.


Patients with nonmelanoma skin cancer (NMSC) may experience symptoms of itch and pain, which we previously reported to be associated with overall degree of inflamation1-3 . Specific mediators underlying itch and pain in NMSCs have not been studied, so immunohistochemistry was performed for mediators involved in these pathways. 60 subjects from a tissue repository3 were included in this study for a total of 50 histopathologically confirmed NMSCs and 10 healthy controls. Participants were asked to rank their current itch and pain intensities at the time and location of biopsy on a 11-point numerical rating scale (NRS).