Immunohistochemistry Analysis of Itch and Pain Mediators in Nonmelanoma Skin Cancer

Skin Cancer
10/06/2020

Fowler E, et al. J Eur Acad Dermatol Venereol 2020.

ABSTRACT

Patients with nonmelanoma skin cancer (NMSC) may experience symptoms of itch and pain, which we previously reported to be associated with overall degree of inflamation1-3 . Specific mediators underlying itch and pain in NMSCs have not been studied, so immunohistochemistry was performed for mediators involved in these pathways. 60 subjects from a tissue repository3 were included in this study for a total of 50 histopathologically confirmed NMSCs and 10 healthy controls. Participants were asked to rank their current itch and pain intensities at the time and location of biopsy on a 11-point numerical rating scale (NRS).