The Immune System and Pathogenesis of Melanoma and Non-melanoma Skin Cancer

Skin Cancer

Adv Exp Med Biol. 2020;1268:211-226. doi: 10.1007/978-3-030-46227-7_11.


Tumor development is the result of genetic derangement and the inability to prevent unfettered proliferation. Genetic derangements leading to tumorigenesis are variable, but the immune system plays a critical role in tumor development, prevention, and production. In this chapter, we will discuss the importance of the immune system as it relates to the development of skin cancer-both melanoma and non-melanoma skin cancers (NMSC).