Medicinal plants towards modeling skin cancer

Skin Cancer

Curr Drug Targets. 2020 Oct 4. doi: 10.2174/1389450121666201005103521. Online ahead of print.


Skin cancer remains a major cause of mortality worldwide. It can be divided into melanoma and non-melanoma cancer which comprises mainly squamous cell carcinoma and basal cell carcinoma. Although conventional therapies have ameliorated the management of skin cancer, the search for chemopreventive compounds is still the most effective and safer strategy to treat cancer. Nowadays, chemoprevention is recognized as a novel approach to prevent or inhibit carcinogenesis steps by the use of natural

products. Crude extracts of plants and isolated phytocompounds are considered chemopreventive agents since they harbor anti-inflammatory, antioxidant and anti-oncogenic properties against many types of diseases and cancers. In this review, we will discuss the therapeutic effect and preventive potential of selected medicinal plants used as crude extracts or as phytocompounds against melanoma and non-melanoma cutaneous cancers.